Early blight is one of the most common foliar diseases of tomato and it is becoming a limiting factor for successful tomato cultivation in Meghalaya. The experiments were conducted to have information on disease incidence at different growth stages of tomato genotypes, disease progress, apparent rate of infection, and in-vitro as well as in-vivo efficacy of botanicals, fungicides and biocontrol agents. The study revealed that among nine genotypes screened against Alternaria solani, MT-1 and BT-106 were found moderately resistant, two susceptible and rests five were highly susceptible. MT-1 showed the east (29.84%) Percent Disease Index (PDI) and the maximumfruit yield (24.02 t/ha) while Rocky had the highest (66.17%) PDI with the minimum fruit yield (12.75 t/ha). Under in-vitro conditions, fungicide Indofil M-45 showed the maximum inhibition on linear mycelial growth of the fungus. A mixture of Asafoetida, turmeric and water (ATW) was more effective than botanical Tricure in checking the growth of the pathogen. The three Trichoderma formulations showed antagonistic effect in dual culture study. Under in-vivo conditions, Indofil-M 45 spray showed the least (25.98%) PDI and the maximum fruit yield (25.62 t/ha) among the fungicides. ATW showed relatively lesser (35.70%) PDI and higher yield (21.83 t/ha) than Tricure. Among the bioagent formulations, Nisarga sprayed plotsshowed least PDI (39.98%) and higher yields (16 t/ha) than Bhoomika.