Turcicum leaf blight is one of the devastating diseases in all the maize growing areas, affecting grain yield up to 90 per cent. It has also become the limiting factor for successful maize cultivation in Meghalaya. Keeping in view with the above facts, the present study was undertaken with objectives viz. assessment of yield losses due to turcicum leaf blight of maize; isolation and identification of native bio-control agents from maize regime; and evaluating the efficacy of botanicals, bio control agents and fungicides both in-vitro and in-vivo for management. The study revealed, the significant differences in different parameters of yield observed between protected and compared unprotected conditions. The yield (t/ha) loss was observed to the tune of 28.17 per cent. The native Trichoderma spp. were isolated from maize regime and collected from laboratory. Under the in-vitro conditions, two plant extracts, two fungicides and five bio-control agents were evaluated. Among the plant extracts, lantana 10% showed maximum inhibition (43.87%) on radial growth of E. turcicum. Mancozeb at both (2.5g/l and 1.25g/l) the doses were found effective. Among five Trichoderma spp., T. harzianum showed 54.14 per cent mycelial inhibition followed by T. viride (53.88%). Under in-vivo conditions, altogether eight treatments with control were used, among them Mancozeb sprayed plots showed the least (18.44%) POI and significant effect on yield attributes in general as compared to other treatments and control. Among the nutrients, K+Zn showed least POI (26.56) followed by P+Zn (27.78) and N+Zn (29.11). The plots sprayed with T. asperellum and Lantana camara showed least POI of 31.11 and 37.22 respectively. The highest (124) AUOPC was observed in control followed by T. asperellum (58.67) treatment. Apparent infection rate was observed highest (0.11) in control.